Written by Geoffrey S. Blunt on August 24, 2018
bottle of Krystexxa

Krystexxa - Does it Work?-Review

What is Krystexxa?

Gout is a type of arthritis that is caused by too much uric acid in the blood. In this Krystexxa review, we will discover what this product can do for your gout problems and will help you decide whether this product is worth trying or not. Krystexxa is a prescribed medicine that claims to reduce the signs and symptoms of gout that are not regulated by other means of treatment or people who still have high uric acid levels after taking some other medicines.

Ingredients & How it Works?

This drug contains the substance called pegloticase, which is the main ingredient of this product. Basically, pegloticase is an enzyme that helps break down uric acid into a harmless chemical called allantoin. Allantoin is a water-soluble substance that can be easily excreted by the body through urination. This tetrameric protein composed of four identical chains of three hundred amino acids is widely used nowadays to treat gout that has not responded positively to other forms of medication. This specific substance may cause some unwanted side effects which includes constipation, sore throat, chest pain, and vomiting. It is also very important to remember that if you have a certain genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency, this product is highly contraindicated as this may cause some life-threatening conditions like hemolysis. Other ingredients include:

  • Disodium hydrogen phosphate dihydrate
  • Sodium chloride
  • Sodium dihydrogen phosphate dihydrate
  • Water for injection

Daily Serving

For adult patients, 8 mg given as an intravenous infusion every two weeks. Since this is a prescribed medication and is administered under the watch of a healthcare practitioner, dosage might vary depending on one's case. It is very important to remember that this medication is administered intravenously. The treatment time usually lasts for around two hours while under the supervision of a doctor or a nurse. There are high risks of some side effects that may occur, the most dangerous being anaphylaxis. So it recommended to be observed for at least an hour after the transfusion is finished.

The Cost

This isn't a cheap over-the-counter tablet or capsule. The cost for Krystexxa falls around the price range of $14,881.00 - $19,750.67 per 8 mg/mL. It will depend on your health insurance, how much you will be covered for.


As with all prescription medications, this product does not have any guarantee. If you are not happy with the results, you will not get any money back.

Our Review Summary Of Krystexxa

This prescription drug might be the answer to the 3% of people who are suffering from gout and have not responded to other medications. However, this product really should only be a last resort. It is a very costly and time-consuming treatment that also has quite a high risk of some very serious side effects. There are many natural products on the market for managing gout which are more cost effective and contain ingredients to reduce uric acid in the body which are worth looking into before going to the extreme of this prescription medication.

Well researched reviews, from the experts at Research & You.